• W F Taylor, A G Finkel, K R Robertson, A C Anderson, T C Toomey, S A Abashian, and J D Mann.
• Neurology Pain Clinic, Department of Neurology, University of North Carolina, Chapel Hill 27599-7025, USA.
• Pain Med. 2000 Sep 1; 1 (3): 254-9.

ObjectiveTo examine the longitudinal use of methadone in a pain clinic.DesignFollow-up study of 40 patients initially treated with methadone and re-evaluated 2 years later, comparing those maintained on methadone with those who were switched to other opioids.SettingPain clinic at a university hospital.ResultsThe 14 patients (35%) who stayed on methadone for the duration of the study, had higher employment rates (P <.05) and higher functional ratings (P <.02) than those on other opioids. Side effects were the most common reason (33.4%) for discontinuation of methadone. Dose escalation occurred in 11 of 14 patients (78.6%).ConclusionsChronic pain patients may be safely and effectively treated with methadone. Those not responding or tolerating methadone may be benefited by treatment with other opioids.

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