• Pain Med · Sep 2001

    Transdermal fentanyl: little absorption in two patients with systemic sclerosis?

    • M Karst, M Fink, T Wagner, and I Conrad.
    • Department of Anesthesiology, Pain Clinic, Hannover Medical School, Germany. Karst.Matthias@MH-Hannover.de
    • Pain Med. 2001 Sep 1; 2 (3): 225-7.

    AbstractTwo patients suffering from systemic sclerosis (SSc) were treated with the 25 micro/hr transdermal fentanyl patch for pain from either deltoid muscle tendinitis of the left arm or from ischemia of the left-hand thumb. When the medication was changed to either oral morphine or oral methadone, the effects did not correspond to the drug conversion table. These findings suggest that patients with SSc and other systemic skin diseases may be at risk for limited absorption of transdermal fentanyl. In contrast, no restriction of the absorption of transdermal testosterone was observed.

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