• J. Neurol. Neurosurg. Psychiatr. · Oct 2019

    Review

    Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience.

    • Evan C Edmond, Charlotte J Stagg, and Martin R Turner.
    • Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.
    • J. Neurol. Neurosurg. Psychiatr. 2019 Oct 1; 90 (10): 1131-1138.

    AbstractThe neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date.© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

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