• Leslie Z Sokolow, Allison L Naleway, De-Kun Li, Pat Shifflett, Sue Reynolds, Michelle L Henninger, Jeannette R Ferber, Roxana Odouli, Stephanie A Irving, Mark G Thompson, and Pregnancy and Influenza Project Workgroup.
• Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA; Battelle, Atlanta, GA. Electronic address: lsokolow@cdc.gov.
• Am. J. Obstet. Gynecol. 2015 Feb 1; 212 (2): 202.e1-11.

ObjectiveThe objective of the study was to identify characteristics of influenza illness contrasted with noninfluenza acute respiratory illness (ARI) in pregnant women.Study DesignARI among pregnant women was identified through daily surveillance during 2 influenza seasons (2010-2012). Within 8 days of illness onset, nasopharyngeal swabs were collected, and an interview was conducted for symptoms and other characteristics. A follow-up telephone interview was conducted 1-2 weeks later, and medical records were extracted. Severity of illness was evaluated by self-assessment of 12 illness symptoms, subjective ratings of overall impairment, highest reported temperature, illness duration, and medical utilization.ResultsOf 292 pregnant women with ARI, 100 tested positive for influenza viruses. Women with influenza illnesses reported higher symptom severity than those with noninfluenza ARI (median score, 18 vs 16 of 36; P < .05) and were more likely to report severe subjective feverishness (18% vs 5%; P < .001), myalgia (28% vs 14%; P < .005), cough (46% vs 30%; P < .01), and chills (25% vs 13%; P < .01). More influenza illnesses were associated with fever greater than 38.9°C (20% vs 5%; P < .001) and higher subjective impairment (mean score, 5.9 vs 4.8; P < .001). Differences in overall symptom severity, fever, cough, chills, early health care-seeking behavior, and impairment remained significant in multivariate models after adjusting for study site, season, age, vaccination status, and number of days since illness onset.ConclusionInfluenza had a greater negative impact on pregnant women than noninfluenza ARIs, as indicated by symptom severity and greater likelihood of elevated temperature. These results highlight the importance of preventing and treating influenza illnesses in pregnant women.Copyright © 2015 Elsevier Inc. All rights reserved.

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