• World Neurosurg · Jul 2019

    Review Meta Analysis

    Meta-analysis of the prognosis of Different treatments of symptomatic moyamoya disease.

    • Qifeng Li, Yalong Gao, Wenqiang Xin, Ziwei Zhou, Hongtao Rong, Yafei Qin, Ke Li, Yuan Zhou, Jiwei Wang, Jianhua Xiong, Xinlong Dong, Mengchen Yang, Yixin Liu, Jun Shen, Guangen Wang, Aiguo Song, and Jianning Zhang.
    • Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, P. R. China; Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, P. R. China.
    • World Neurosurg. 2019 Jul 1; 127: 354-361.

    ObjectiveThe purpose of this study was to evaluate the efficacy of surgical revascularization versus conservative treatment and different surgical modalities, in order to provide evidence for the patient with moyamoya disease (MMD) to choose the appropriate treatment.MethodsWe comprehensively searched PubMed, Embase, Web of Science, and the Cochrane Library for articles published regarding MMD treatment. If the I2 value, which evaluated the heterogeneity, was <50%, a fixed-effect model was used; if not, a random effect model was applied.ResultsTwenty-seven articles were included in the meta-analysis. The surgery group is more advantageous in reducing the risk of future stroke events than conservative treatment in MMD patients (odds ratio [OR] 0.26, 95% confidence interval [CI] 0.20-0.33, P < 0.001). In addition, the surgical group also had an advantage in terms of increased cerebral perfusion (OR 7.16, 95% CI 3.28-15.64, P < 0.001) and death due to rebleeding (OR 0.27, 95% CI 0.10-0.72, P < 0.01). Direct surgery showed a significant efficacy over indirect surgery (OR 2.03, 95% CI 1.32-3.13, P < 0.01). No obvious difference was found between the direct and indirect bypass subset (OR 0.76, 95% CI 0.51-1.14, P = 0.185). Angiographic results in patients undergoing direct bypass surgery are more pronounced (OR 0.20, 95% CI 0.06-0.67, P < 0.01).ConclusionsIn patients with symptomatic moyamoya disease, bypass surgery is more effective than conservative treatment to prevent future strokes. In surgical patients, direct bypass seems to reduce the risk of stroke more than an indirect bypass.Copyright © 2019 Elsevier Inc. All rights reserved.

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