• World Neurosurg · Jul 2019

    Review

    What is the optimal timing and sequence of immunotherapy when used in combination with stereotactic radiation in the treatment of brain metastases?

    • Mahmoud ElJalby, Susan C Pannullo, Theodore H Schwartz, Bhupesh Parashar, and A Gabriella Wernicke.
    • Weill Medical College of Cornell University, New York, New York, USA.
    • World Neurosurg. 2019 Jul 1; 127: 397-404.

    AbstractCheckpoint immunotherapy (CIT) is an emerging and exciting treatment modality for the treatment of cancer. Much excitement has ensued in the potential of CIT to revolutionize the treatment and prognosis of brain metastases. The combination of stereotactic radiosurgery (SRS) and CIT has also been studied and showed promise compared with either treatment modality alone. However, several questions have arisen, in particular, the timing at which SRS and CIT should be administered relative to each other. We reviewed the reported data and attempted to offer a potential answer to this question.Copyright © 2019 Elsevier Inc. All rights reserved.

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