• World Neurosurg · Jul 2019

    Case Reports

    Froin's syndrome after Spinal Cord Injury.

    • Thomas Decramer, Anke Wouters, Carlotte Kiekens, and Tom Theys.
    • Department of Neurosurgery, University Hospitals, Leuven, Belgium. Electronic address: thomas.decramer@uzleuven.be.
    • World Neurosurg. 2019 Jul 1; 127: 490-491.

    BackgroundFroin syndrome is characterized by xanthochromia and hypercoagulability of the cerebrospinal fluid (CSF) due to elevated protein levels. This entity results from blockage of the spinal canal by a mass lesion leading to an isolated caudal CSF space.Case DescriptionA 48-year-old male, who developed spasticity after a C6 spinal cord injury (SCI) 20 years earlier, presented with subobstruction of his intrathecal baclofen pump. A catheter access port aspiration revealed an extremely high protein concentration (38 g/L) with no signs of infection. Froin syndrome was confirmed when magnetic resonance imaging showed a complete obstruction of the spinal canal at the SCI level.ConclusionsWe report the first case of Froin syndrome after SCI. Froin syndrome can impact intrathecal drug delivery and CSF diagnostics.Copyright © 2019 Elsevier Inc. All rights reserved.

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