• David Skarupa, Firas Madbak, David Ebler, Albert Hsu, Madeline B Torres, Donald Johnson, Gazanfar Rahmathulla, Andrew J Kerwin, Jin Ra, Joseph Shiber, and Marie Crandall.
• Department of Surgery, University of Florida College of Medicine Jacksonville, Jacksonville, Florida; Department of Neurosurgery, University of Florida College of Medicine Jacksonville, Jacksonville, Florida.
• World Neurosurg. 2019 Aug 1; 128: e552-e555.

BackgroundAntibiotics after spine instrumentation are often extended while the surgical drain is in place, particularly for traumatic injuries. We sought to study if continuing antibiotics past 24 hours affected outcomes.MethodsWe performed a retrospective observational study of all patients who underwent spine fixation with hardware and surgical drains for trauma at our institution. We compared the effect of perioperative (≤24 hours of antibiotics) versus prolonged (>24 hours) antibiotics on surgical outcomes. Bivariate and multivariable logistic and linear regression statistics were performed.ResultsThree hundred and forty-six patients were included in the analysis. On multivariate analysis, antibiotic duration >24 hours did not predict surgical site infection (odds ratio, 2.68; 95% confidence interval, 0.88-8.10, P = 0.08) or mortality (odds ratio, 0.59; 95% confidence interval, 0.10-3.44; P = 0.56).ConclusionsContinuing antibiotics past 24 hours after traumatic spine instrumentation was not associated with improved outcomes. A prospective study to verify these findings may be warranted.Copyright © 2019 Elsevier Inc. All rights reserved.

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