• Br J Anaesth · Oct 2003

    Release by hypoxia of a soluble vasoconstrictor from rabbit small pulmonary arteries.

    • N P Talbot, P A Robbins, and K L Dorrington.
    • University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK.
    • Br J Anaesth. 2003 Oct 1; 91 (4): 592-4.

    BackgroundSoluble pulmonary vasoconstrictors released in response to hypoxia have been reported in pig and rat preparations, but not in rabbit preparations.MethodsWe used myography to evaluate the contribution of a soluble factor to constriction in rabbit small pulmonary arteries (external diameter 300-475 microm) exposed to 45 min hypoxia (PO(2)=9 mm Hg).ResultsHypoxia produced gradually intensifying constriction. Return to euoxia (PO(2)=145 mm Hg) for 30 min relaxed only approximately 30% of the constriction, whereas elution of the myograph bath yielded full relaxation. Reapplication of the eluent gradually restored the constriction to its pre-elution level over a 30-min period.ConclusionsIn this closed system, a soluble factor contributes substantially to hypoxic pulmonary vasoconstriction.

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