• Aurélien Bataille, Avit Guirimand, Barbara Szekely, Mireille Michel-Cherqui, Virginie Dumans, Ngai Liu, Thierry Chazot, Marc Fischler, and Morgan Le Guen.
• From the Department of Anaesthesia, Burn and Critical Care, University Hospitals Saint Louis Lariboisière (AB), University Paris Diderot (AB), Department of Anaesthesia, Foch Hospital, Paris (AG, BS, MM-C, VD, NL, TC, MF, MLG) and University Versailles Saint-Quentin en Yvelines, Versailles, France (AG, BS, MM-C, VD, NL, TC, MF, MLG).
• Eur J Anaesthesiol. 2018 Sep 1; 35 (9): 675-681.

BackgroundHypnosis has a positive effect on peri-operative anxiety and pain.ObjectiveThe objective of this study was to assess the impact of a formal deep hypnosis session on the consumption of propofol for anaesthetic induction using automated administration of propofol guided by the bispectral index (BIS) in a closed loop.DesignA 1 : 1 randomised, usual-care-controlled, single-centre trial.SettingTertiary care centre in France from April 2014 to December 2015.PatientsFemale adult patients scheduled for outpatient gynaecological surgery under general anaesthesia.InterventionBefore surgery, patients were randomised to receive either a deep hypnosis session or routine care. Anaesthetic induction was performed automatically by propofol without opioids and was assisted by the BIS in a closed loop.Main Outcome MeasuresThe primary endpoint was the propofol dose required for anaesthesia induction, defined as a BIS less than 60 for at least 30 s.ResultsData for 31 patients in the hypnosis group and 35 in the control group were analysed. There was no evidence of a difference in the mean required propofol dose for anaesthetic induction between the hypnosis and the control groups (2.06 mg kg (95% confidence interval [1.68 to 2.43]) versus 1.79 mg kg (95% CI [1.54 to 2.03]), P = 0.25, respectively).ConclusionThe current study, which was designed to determine the effect of a deep hypnosis session on anaesthesia induction using an automated tool for propofol administration, failed to detect a difference in the required dose of propofol.Trial RegistrationClinicalTrials.gov, NCT02249364.

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