• Jifu Jin, Su Chi Chang, Sujuan Xu, Jiarui Xu, Wuhua Jiang, Bo Shen, Jiachang Hu, Yamin Zhuang, Chunsheng Wang, Jie Teng, and Xiaoqiang Ding.
• Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Medical Center of Kidney Disease, Shanghai, China; Shanghai Institute of Kidney and Dialysis, Shanghai, China; Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China.
• J. Cardiothorac. Vasc. Anesth. 2019 Oct 1; 33 (10): 2695-2702.

ObjectivesCumulative fluid overload may influence acute kidney injury (AKI) diagnosis due to the dilution effect. The authors hypothesized a small increase of early postoperative serum creatinine (SCr) adjusted for fluid balance might have superior discrimination ability in subsequent AKI prediction.DesignRetrospective analyses.SettingA single-center study in a university hospital.ParticipantsThe study comprised 1,016 adult patients who underwent elective isolated or combined valve surgery in 2015.InterventionsNone.Measurements And Main ResultsBaseline characteristics, intraoperative parameters, and intraoperative and postoperative fluid balance were collected through a retrospective chart review. Early postoperative SCr level was drawn within 12 hours of surgical completion and then measured daily. Early relative changes of SCr were categorized as a cutoff value of 10% with or without adjustment for cumulative fluid balance. Kidney Disease: Improving Global Outcomes criteria were used to detect AKI. Logistic analyses were performed to determine risk factors for subsequent AKI with the inclusion of measured or fluid-adjusted early relative changes of SCr, respectively. In this study, 355 patients (34.9%) developed AKI. Multivariate logistic analyses showed age, weight, European System for Cardiac Operative Risk Evaluation II, and cardiopulmonary bypass duration were associated independently with the development of AKI. Model discrimination for AKI prediction was improved significantly when the addition of measured (area under the receiver operating characteristic curve [AUROC] 0.830) and fluid-adjusted early changes of SCr to the basic model (AUROC 0.850).ConclusionsEarly fluid-adjusted relative changes of SCr could improve the predictive ability for subsequent development of AKI in valve surgery patients.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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