• Thomas Wiesmann, Ivo Hüttemann, Nora Schilke, Thomas Heyse, Turgay Efe, Daphne Eschbach, Hinnerk Wulf, Thorsten Steinfeldt, and Carsten Feldmann.
• From the Department of Anaesthesiology and Intensive Care Medicine, University Hospital Marburg (TW, IH, NS, HW, TS, CF), Centre for Orthopaedics and Trauma Surgery, University Hospital Giessen and Marburg, Campus Marburg, Marburg (TH, TE, DE) and Department of Anaesthesiology and Intensive Care Medicine, Diakoniekrankenhaus Schwäbisch Hall, Schwäbisch Hall, Germany (TS).
• Eur J Anaesthesiol. 2018 Oct 1; 35 (10): 782-791.

BackgroundCombining continuous femoral nerve blockade with single injection sciatic nerve blockade is standard peripheral nerve block practice for total knee arthroplasty (TKA) during the first 24 postoperative hours.ObjectivesTo assess the analgesic benefits and mobilisation capability of continuous sciatic blockade in conjunction with continuous femoral nerve blockade for 72 h after arthroplasty.DesignRandomised, triple-blinded controlled trial.SettingSingle-Centre, German University Hospital.PatientsIn total, 50 patients receiving continuous femoral nerve blockade (5 ml h ropivacaine 0.2%) for TKA under general anaesthesia.InterventionsPatients were randomised to receive a sciatic nerve catheter with an initial dose of 10 ml ropivacaine 0.2% followed by either continuous double-blinded application of 5 ml h ropivacaine 0.2% (CO) or 5 ml h saline infusion (SIN).Main OutcomeMeasures primary endpoint: cumulative morphine consumption until 48 h postoperatively. Further endpoints included morphine consumption, pain scores, mobilisation, dynamometry until postoperative day 3.ResultsMedian [25th to 75th percentiles] cumulative morphine consumption at postoperative day 2 differed significantly between groups (CO 15 mg [11 to 25] versus SIN, 43 mg [27 to 67.5, P < 0.0001) in the 48 patients in the final analysis. Overall pain scores were comparable at rest and during stress at each time point. However, significantly higher pain scores of the popliteal fossa were observed in the SIN group. Mobilisation was comparable between groups.ConclusionThis trial demonstrates the superior analgesic effects of continuous sciatic nerve block compared with a single injection in combination with continuous femoral blockade during the first 72 h after TKA. However, mobilisation capability was impaired in both groups. Improved pain control from two catheters needs to be balanced against the potential risks of impaired mobilisation and patient falls.Trial RegistrationDRKS - German clinical trials register (no: DRKS00010152).

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