• Dan Zhang, Haiyi Gong, Mao Shen, Da Wang, Jian Jiao, Xinghai Yang, Tielong Liu, Haifeng Wei, Zhipeng Wu, and Jianru Xiao.
• Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
• World Neurosurg. 2019 Sep 1; 129: e330-e336.

BackgroundThyroid cancer, one of the most common endocrine malignancies in developed areas and China, is associated with favorable prognosis. However, the presence of spinal metastases will remarkably reduce the life expectancy for patients with thyroid cancer. In addition, limited information is available about such disease.MethodsVarious potential clinical factors were submitted to univariate and multivariate analyses to identify the independent variables that predicted the prognosis for patients. In addition, the survival rate was estimated according to the Kaplan-Meier method, and statistic differences were calculated by the log-rank test. Moreover, factors with a P value of ≤0.1 were performed multivariate analysis using a multivariate Cox proportional hazards model, and factors with a P value of <0.05 were considered as statistically significant.ResultsSeven potential independent prognostic factors had been identified through univariate analysis, which were then subjected to multivariate analysis. Our results suggested that age of ≤50 years, single segment involved, and follicular thyroid cancer were the independent favorable prognostic factors.ConclusionsFindings in this study indicate that age of ≤50 years, single segment involved, and follicular thyroid cancer are favorable prognostic factors for patients with thyroid cancer spinal metastases.Copyright © 2019 Elsevier Inc. All rights reserved.

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