• Sen Liu, Nan Wu, Jiaqi Liu, Hao Liu, Xinlin Su, Zhenlei Liu, Yuzhi Zuo, Weisheng Chen, Gang Liu, Yixin Chen, Yue Ming, Tangmi Yuan, Xiao Li, Jun Chen, Zenan Xia, Shengru Wang, Jia Chen, Tao Liu, Xu Yang, Yufen Ma, Jianguo Zhang, Jianxiong Shen, Shugang Li, Yipeng Wang, Hong Zhao, Keyi Yu, Yu Zhao, Shishu Huang, Xisheng Weng, Guixing Qiu, Chao Wan, Guangqian Zhou, and Zhihong Wu.
• Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, Beijing 100730, P.R. China.
• J. Orthop. Res. 2016 May 1; 34 (5): 860-4.

AbstractLow back pain (LBP) is a common health problem and many LBP are caused by lumbar disc degeneration (LDD). ADAMTS-4 (a disintegrin and metalloprotease with thrombospondin motifs-4), also known as aggrecanse-1, plays a core role in degeneration of extracellular matrix in LDD. To investigate the association between ADAMTS-4 genetic polymorphism and LDD, we genotyped SNPs in and around ADAMTS-4. We recruited 482 sporadic cases of LDD and 496 healthy controls from Chinese Han population. Five SNPs were selected and phenotyped by the Sequenom MassARRAY system. Allelic, genotypic, and haplotypic association was performed. Rs4233367 (c.1877 C>T), which located in exon of ADAMTS-4 showed significant association with LDD. The T allele conferred a lower risk of LDD with an OR of 0.69 and TT genotype is at nearly one-fifth of the risk compared to CC genotype. Other tested SNPs didn't show significant difference between the case and control groups. The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:860-864, 2016.© 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

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