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Semin Respir Crit Care Med · Apr 2019
ReviewHistology of Pulmonary and Bronchiolar Disorders in Connective Tissue Diseases.
- Cecilia Brambilla, Alexandra Rice, and Andrew G Nicholson.
- Department of Histopathology, Royal Brompton Hospital and Harefield NHS, London, United Kingdom.
- Semin Respir Crit Care Med. 2019 Apr 1; 40 (2): 147-158.
AbstractConnective tissue diseases (CTDs) are a heterogeneous group of disorders, acquired or hereditary, involving an autoimmune-mediated inflammation of connective tissues in the whole body. Lung involvement is common with CTDs, and associated with significant morbidity and mortality. Each compartment of the lung may be affected, often simultaneously, depending on the type of CTD. In addition, the lung may show pathological changes related to treatment, such as infection, drug reaction, and neoplasia. A multidisciplinary approach to diagnose these patients is essential and incorporates radiological and clinical as well as pathological data. In this review we describe the patterns of lung disease associated with common CTDs, lung disease in pediatric CTD patients, and newly recognized conditions.Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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