• Trans. R. Soc. Trop. Med. Hyg. · Aug 2006

    Case Reports

    First case of ivermectin-induced severe hepatitis.

    • Olivia Veit, Bernhard Beck, Michael Steuerwald, and Christoph Hatz.
    • Swiss Tropical Institute, Medical Department, Socinstrasse 57, 4002 Basle, Switzerland. oviet@yahoo.com
    • Trans. R. Soc. Trop. Med. Hyg. 2006 Aug 1; 100 (8): 795-7.

    AbstractLoiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa. Ivermectin has been shown to be an effective treatment of loiasis. We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin. Liver biopsy showed intralobular inflammatory infiltrates, confluent necrosis and apoptosis, compatible with drug-induced liver disease. To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.

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