• Yasin Bayir, Harun Un, Rustem Anil Ugan, Erol Akpinar, Elif Cadirci, Ilknur Calik, and Zekai Halici.
• Faculty of Pharmacy, Department of Biochemistry, Ataturk University, Erzurum, Turkey. Electronic address: ybayir@atauni.edu.tr.
• Burns. 2019 Sep 1; 45 (6): 1410-1417.

BackgroundBeeswax, Olive oil and Butter (BOB) are nutritive products that could support wound healing by adsorption to bandage. This study demonstrated the therapeutic effects of BOB on second degree burn.MethodsSecond degree burn model was created in rats. Experimental groups were assigned to Healthy, Burn, Silver Sulfadiazine (SS) and BOB. The effects of BOB were evaluated on skin regeneration, vesicles and bullae and fibroblast activity by histopathological analyses and wound contraction percent were determined. Transforming Growth Factor-Beta1 (TGF-β1) and Vascular Endothelial Growth Factor-alpha (VEGF-α) mRNA expressions were analyzed with Real Time-Polymerase Chain Reaction. All parameters analyzed at 3rd, 7th, 14th days.ResultsThe BOB treatment increased TGF-β1 and VEGF-α expressions compared to Burn group. The histopathological analyses showed that epidermis and dermis layers injured due to burn. BOB treatment augmented the regeneration of these layers and increased fibroblast activity and keratinization which are play important role on the new blood vessels production. Also with the BOB treatment we showed wound contraction levels were higher than Burn and SS treatment.ConclusionThis study demonstrated that beeswax-olive oil-butter mixture impregnated bandage treatment in a second-degree burn rat model improved burn wound healing and encouraged skin renewal via modulating tissue TGF-β1 and VEGF-α.Copyright © 2018 Elsevier Ltd and ISBI. All rights reserved.

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