• World Neurosurg · Sep 2019

    Combined hyperactive dysfunction syndrome of the cranial nerves: analysis of 37 cases and literature review.

    • Yong-Qiang Zhang, Feng Yu, Zhen-Yu Zhao, and Xue-Zhong Men.
    • Department of Neurosurgery, PLA 960th Hospital, Jinan, Shandong Province, China.
    • World Neurosurg. 2019 Sep 1; 129: e650-e656.

    BackgroundHyperactive dysfunction syndrome (HDS) of the cranial nerves, such as trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia (GPN), is commonly managed by microsurgical treatment. However, certain patients may present a combination of these syndromes in the neurosurgery department. Here, we aimed to retrospectively assess patients with combined HDS from a single center.MethodOf 1275 consecutive patients with HDS treated at our center between 2007 and 2017, 37 patients with combined HDS were enrolled, and their medical and surgical records were analyzed.ResultsThe patients with combined HDS, accounting for 2.9% of all patients with HDS, included 22 patients with bilateral TN, 5 patients with TN-HFS, 8 patients with TN-GPN, and 2 patients with GPN-HFS. A comparison of patients with single and combined HDS indicated a significant difference in the mean age at initial diagnosis (63.57 vs. 56.18 years, P = 0.000) but no such difference in the sex ratio (0.54 vs. 0.59, P = 0.865) or incidence of hypertension (32.43% vs. 24.56%, P = 0.274). In total, 32 microvascular decompression (MVD) procedures were performed in the 27 patients with combined HDS, and repeated MVD was required in 5 patients with bilateral TN. Of the 27 patients who underwent MVD, 25 (92.6%) experienced clinical cure or obvious alleviation.ConclusionsCombined HDS involves a group of functional disturbance disorders affecting specific cranial nerves, and it may include TN, HFS, and GPN. In addition to gender and incidence of hypertension, age appeared to be a vital indicator for the development of combined HDS, although this finding was inconsistent in previous studies. MVD appears to be a safe and effective treatment for combined HDS, with a high rate of long-term success.Copyright © 2019 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…