• Olavo B de Oliveira-Neto, Fabiano Timbo Barbosa, Celio Fernando de Sousa-Rodrigues, and Fernando Jose Camello de Lima.
• Research assistant, Federal University of Alagoas Dental School (FOUFAL), Maceio, Brazil. Electronic address: olavobarbosa91@gmail.com.
• J Prosthet Dent. 2018 Aug 1; 120 (2): 198-203.

Statement Of ProblemAlthough dental implant treatment has a high success rate, patient-related factors may cause implant failure. In this context, smoking is associated with adverse effects on implant osseointegration. In spite of systematic reviews addressing this topic, the risk of bias in these reviews must be assessed to inform readers whether the studies were conducted with methodological rigor and whether their recommendations are viable in daily clinical practice.PurposeThe purpose of this umbrella systematic review was to assess the risk of bias of systematic reviews regarding dental implant placement in smokers.Material And MethodsSystematic review articles with meta-analysis regarding dental implant placement in smokers were eligible for this study. The following were excluded: articles in which implant survival or failure rate was not the primary outcome; articles in which implant survival or failure rate was not related to smokers; and duplicated articles. The search was performed by 2 independent reviewers on MEDLINE (PubMed), Scopus, Web of Science, LILACS, DARE-Cochrane, and SIGLE via OpenGrey. Non-peer-reviewed literature was sought on SIGLE via OpenGrey without language restrictions. Reviewers read titles and/or abstracts to select potential eligible studies, and articles initially selected were read fully. A third reviewer was consulted in cases of disagreement. References of the selected articles were also screened to identify articles of potential interest. The last search was performed on April 29, 2017. Risk of bias assessment was performed with the Risk of Bias in Systematic Reviews (ROBIS) tool.ResultsOf the initial 2539 results, 6 systematic reviews with meta-analysis were eligible for the umbrella review (kappa=0.90; very good agreement). All studies were published in the last 11 years. One meta-analysis (16.7%) presented low risk of bias, 3 (50.0%) were assessed as of unclear risk of bias, and 2 (33.3%) received a score of high risk of bias according to the assessment with the ROBIS tool, which also indicated that the criteria most commonly not met were study eligibility criteria and identification and selection of studies.ConclusionsFive of the 6 included meta-analyses had a risk of bias (high or unclear). Therefore, their conclusions and recommendations required careful review. Future meta-analyses must focus especially on study eligibility criteria and identification and selection of studies.Copyright © 2018 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

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