• Ekaterini Syrigou, Dimitra Grapsa, Andriani Charpidou, and Konstantinos Syrigos.
• Allergy Department, "Sotiria" General Hospital, Athens, Greece.
• J Cutan Med Surg. 2015 Nov 1; 19 (6): 592-4.

AbstractDrug-induced acute generalized exanthematous pustulosis is a rare pustular skin reaction, most commonly triggered by antibiotics. Although its diagnosis is based primarily on the presence of specific clinical and histopathologic features, additional in vivo (patch testing) or in vitro testing may be required, especially in atypical cases, to more accurately determine the causative agent. The authors report a histologically confirmed case of acute generalized exanthematous pustulosis that was induced by amoxicillin/clavulanic acid, as documented by subsequent patch testing, and presented with generalized painful lymphadenopathy, mimicking an acute infectious process. This is a very rare and diagnostically challenging clinical presentation of acute generalized exanthematous pustulosis, which has been reported, to the best of our knowledge, only once previously. © The Author(s) 2015.

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