• Milena Binhame Albini, Ingra Taís Malacarne, Thiago Beltrami Dias Batista, Antônio Adilson Soares de Lima, Maria Angela Naval Machado, Aline Cristina Batista Rodrigues Johann, Rosa Edvaldo Antonio Ribeiro EAR, and Luciana Reis Azevedo-Alanis.
• Pontifícia Universidade Católica do Paraná, PUCPR, Curitiba, Brazil.
• Eur Addict Res. 2017 Jan 1; 23 (2): 77-86.

AimsTo evaluate cytological alterations, inflammation, and microbial charge of the oral mucosa epithelium in crack users in in terms of the amount and duration of use.MethodsTwo hundred thirty four crack users (case group) and 120 non-users (control group) participated in this study. Clinically healthy epithelial cells were collected from the posterior mouth floor, using the conventional exfoliative cytology. Some of the aspects evaluated were as follows: Papanicolaou classification, nuclear area (NA), cytoplasmic area (CA), nuclear/cytoplasmic area ratio (NA/CA), inflammation, microbial charge, keratinization, enucleated superficial cells, and binucleation.ResultsThe average time of crack consumption was 9.8 years (±7.1) and the average quantity of use was 13.97 g/week (±18.5). The average NA values and NA/CA ratio were increased and CA values were decreased in the case group compared to those in the controls (p < 0.05). Papanicolaou class II, intense inflammation, and intense microbial charge were more prevalent in the case group than in the controls (p < 0.05). There was a significant association between high quantity of smoked crack rocks per week and increased CA values, absence of keratinization, and presence of enucleated superficial cells (p < 0.05).ConclusionCrack use seemed to induce inflammatory alterations and early indicators of malignant transformation on the oral mucosa epithelium.© 2017 S. Karger AG, Basel.

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