• Curr Rheumatol Rep · Jul 2013

    Review

    Ten developments in the use of biologicals for systemic lupus erythematosus.

    • Daniel J Wallace.
    • Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dwallace@ucla.edu
    • Curr Rheumatol Rep. 2013 Jul 1; 15 (7): 337.

    AbstractBelimumab has recently been approved, and several other types of biological therapy with different mechanisms of action are currently in phase II and III studies. This review puts these approaches in context, emphasizing mechanistic categories and clinical trial designs. Most of the promising approaches involve B cell depletion or modulation. Post-approval experience with belimumab is critically reviewed.

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