• Aaron Conger, Daniel M Cushman, Rebecca A Speckman, Taylor Burnham, Masaru Teramoto, and Zachary L McCormick.
• Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, Utah.
• Pain Med. 2020 Jan 1; 21 (1): 41-54.

ObjectiveDetermine the effectiveness of fluoroscopically guided cervical transforaminal epidural steroid injection (CTFESI) for the treatment of radicular pain.DesignSystematic review and meta-analysis.SubjectsPersons aged ≥18 years with cervical radicular pain due to disc herniation or degenerative spondylosis.ComparisonSham, placebo procedure, or active standard of care treatment, excluding alternative versions of epidural steroid injection.OutcomesThe primary outcome measure was patient-reported improvement in pain of at least 50% from baseline, assessed four or more weeks after the treatment intervention. Secondary outcomes included validated functional assessment tools and avoidance of spinal surgery.MethodsRandomized or nonrandomized comparative studies and nonrandomized studies without internal control were included. Three reviewers independently assessed publications in the Medline, PubMed, and Cochrane databases up to July 2018. The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system was used to evaluate risk of bias and overall quality of evidence. A meta-analysis was conducted for comparative measures of effect and for within-group response rates if applicable.ResultsThere were no studies with an internal comparison group (control group) meeting the review's definition of comparison group. Therefore, comparative measures of effect were not calculated. In cohort studies, pooled response rates were 48% (95% confidence interval [CI] = 34-61%) at one month and 55% (95% CI = 45-64%) at three months.ConclusionsApproximately 50% of patients experience ≥50% pain reduction at short- and intermediate-term follow-up after CTFESI. However, the literature is very low quality according the GRADE criteria, primarily due to a lack of studies with placebo/sham or active standard of care control comparison groups.© 2019 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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