• Jordi Valles, Dionisia Fontanals, Joan Carles Oliva, Melcior Martínez, Ana Navas, Jaume Mesquida, Guillem Gruartmoner, Candelaria de Haro, Jaume Mestre, Consuelo Guía, Andrey Rodriguez, Eva Torrents, Cristina Espinal, Ana Ochagavía, and Emili Diaz.
• Critical Care Department, Hospital Universitari Parc Taulí, Sabadell, Spain. Electronic address: jvalles@tauli.cat.
• J Crit Care. 2019 Oct 1; 53: 46-52.

PurposeTo evaluate the incidence and mortality of adult patients with community-acquired septic shock (CASS) and the influence of source control (SC) and other risk factors on the outcome.Material And MethodsThe study included patients with CASS admitted to the ICU at a university hospital (2003-2016). Multivariate analyses were performed to identify risk factors of ICU mortality.ResultsA total of 625 patients were included. The incidence showed an average annual increase of 4.9% and the mortality an average annual decrease of 1.4%. The patients who required SC showed a lower mortality (20.4%) than patients who did not require SC (31.3%) (p = 0.002). However, the evolution in mortality was different: Mortality decreased in patients who did not require SC (from 56.3% to 20%; p = 0.02), but did not differ in those who required SC (from 21.4% to 27.6%; p = 0.43). In the multivariate analysis, severity at admission, age, alcoholism, cirrhosis, ARDS, neutropenia and thrombocytopenia were associated with worse outcome, whereas appropriate antibiotic treatment and adequate SC were independently associated with better survival.ConclusionsThe incidence of CASS increased and the ICU mortality decreased during the study period. The mortality was mainly due to a decrease in mortality in infections not requiring SC.Copyright © 2019. Published by Elsevier Inc.

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