• Ignacio Martin-Loeches, Jean Francois Timsit, Marc Leone, Jan de Waele, Massimo Sartelli, Steve Kerrigan, Azevedo Luciano Cesar Pontes LCP Cardiovascular Infection Research Group, Irish Centre for Vascular Biology, School of Pharmacy, Molecular and Cellular Therapeutics, Roya, and Sharon Einav.
• Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, Dublin, Ireland; Respiratory Institute, Hospital Clinic of Barcelona, IDIBAPS, Pulmonary Intensive Care Unit, Barcelona, Spain; CIBEes, Barcelona, Spain. Electronic address: drmartinloeches@gmail.com.
• J Crit Care. 2019 Oct 1; 53: 53-58.

AbstractSepsis is a deadly condition in which the outcome is associated with prompt and adequate recognition, intensive supportive care, antibiotic administration and source control. This last item makes abdominal sepsis a unique treatment challenge. Although pneumonia constitutes the leading cause of sepsis, abdominal sepsis has unique features that merit discussion. The abdomen may be implicated as the primary occult, secondary dependent or secondary independent source of infection. The major factors determining whether a patient will develop an uncomplicated infection or septic shock are: (1) patient susceptibility to infections, (2) age, and (3) comorbidities. The epidemiology of abdominal sepsis and its outcomes are difficult to assess due to the large clinical heterogeneity associated with this entity. Further complicating issues is the debate surrounding the effect of early source control (i.e. the "surgeon effect"). This review evaluates and summarizes the current approach to current challenges in patient care and which are the future research directions.Copyright © 2019. Published by Elsevier Inc.

8 keywords...

hide…