• J. Cardiothorac. Vasc. Anesth. · Dec 2019

    Randomized Controlled Trial

    Could Short-Term Perioperative High-Dose Atorvastatin Offer Antiarrhythmic and Cardio-Protective Effects in Rheumatic Valve Replacement Surgery?

    • Essam Abd Allah, Emad Zarief Kamel, Hany M Osman, Sayed Kaoud Abd-Elshafy, Fatma Nabil, Tarek Taha Hanafy Elmelegy, Hussein Elkhayat, Abdelrady Shehata Ibrahim, and Ahmed Al Minshawy.
    • Anesthesia and ICU department, Faculty of Medicine, Assiut University, Assiut, Egypt.
    • J. Cardiothorac. Vasc. Anesth. 2019 Dec 1; 33 (12): 3340-3347.

    ObjectivesTo evaluate the role of prophylactic high-dose atorvastatin for prevention of postoperative atrial fibrillation (POAF), inflammatory response attenuation, and myocardial protection after valve replacement cardiac surgery.DesignRandomized controlled trial.SettingAssiut University Hospitals.ParticipantsSixty-four adult patients undergoing cardiac valve replacement surgery.InterventionsThe participants were equally divided into 2 groups. Group S received 80 mg of atorvastatin (oral tablets), 12 and 2 hours preoperatively, and on the 2nd, 3rd, 4th, and 5th postoperative days. Control group C received placebo at the same time periods.MeasurementsThe incidence of POAF, postoperative white blood cell count, serum C-reactive protein, interleukin 6, and troponin I.Main ResultsGroup S patients showed a lower incidence of POAF compared with the placebo group (p = 0.031). The white blood cell count showed significant reductions in group S compared with group C on the second, third, fourth, and fifth postoperative days. The C-reactive protein level showed significant reductions on the third, fourth, and fifth postoperative days in group S compared with group C (p = 0.001, 0.001, and 0.001, respectively). The serum level of interleukin 6 showed a significant reduction on the fifth postoperative day in group S compared with group C (p = 0.001). There was no significant difference between the 2 groups regarding the troponin I level and inotropic score.ConclusionProphylactic use of high dose atorvastatin can decrease the incidence of POAF and attenuate the inflammatory process in adult patients undergoing isolated rheumatic cardiac valve replacement surgery.Copyright © 2019 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…