• J. Infect. Dis. · Mar 2016

    Randomized Controlled Trial Multicenter Study

    Estimation of the Antirelapse Efficacy of Tafenoquine, Using Plasmodium vivax Genotyping.

    • Hans-Peter Beck, Rahel Wampfler, Nick Carter, Gavin Koh, Lyda Osorio, Ronnatrai Rueangweerayut, Srivcha Krudsood, Marcus V Lacerda, Alejandro Llanos-Cuentas, Stephan Duparc, Justin P Rubio, and Justin A Green.
    • Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute University of Basel.
    • J. Infect. Dis. 2016 Mar 1; 213 (5): 794-9.

    UnlabelledPrevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled phase 2b study in Peru, India, Thailand, and Brazil allowed determination of genetically heterologous or homologous P. vivax infection recurrence following receipt of chloroquine plus one of 4 doses of tafenoquine (50, 100, 300, or 600 mg) or chloroquine plus primaquine, compared with receipt of chloroquine alone. The antihypnozoite efficacy of tafenoquine was evident as a reduction in homologous recurrences of P. vivax infection as drug doses were increased. No clear dose-response pattern was evident for heterologous recurrences of P. vivax infection. Rates of homologous recurrence of P. vivax infection appear to be clinically useful for comparing drug efficacy for the prevention of P. vivax infection relapse.Clinical Trials RegistrationNCT01376167.© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…