• Neurophysiol Clin · Apr 2000

    Case Reports

    Nonconvulsive status epilepticus: the role of morphine and its antagonist.

    • F Bertran, P Denise, and P Letellier.
    • Service d'explorations fonctionnelles neurologiques, IFR neuro-imagerie fonctionnelle, centre hospitalier universitaire, Caen, France.
    • Neurophysiol Clin. 2000 Apr 1; 30 (2): 109-12.

    AbstractA 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma. A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone. No cerebral lesion was detected. This observation supports the notion of a possible pro-epileptogenic effect of opioid substances in association with metabolic and other toxic factors. Various hypotheses as to the complex actions of morphine and its antagonist in epileptogenesis are discussed.

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