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Mult Scler Relat Disord · Sep 2016
Case ReportsInfluenza vaccination increases anti-JC virus antibody levels during treatment with Natalizumab: Case report.
- Jahir Andres Miranda Acuña and Bianca Weinstock-Guttman.
- Department of Neurology, Hospital General Universitario Gregorio Marañon, C/ Doctor Esquerdo, 46, 28007 Madrid, Spain. Electronic address: jahirmiranda@yahoo.com.co.
- Mult Scler Relat Disord. 2016 Sep 1; 9: 54-5.
BackgroundNatalizumab (NTZ) is an effective therapy for multiple sclerosis (MS). A common concern related to NTZ therapy is the risk of developing progressive multifocal leukoencephalopathy (PML).Clinical CaseA patient that after seven years on NTZ therapy, testing on every 3 months repeated evaluations negative for anti-JCV status became positive (>3 units) 4 weeks after receiving influenza vaccine. Despite continuous therapy on NTZ for additional 2 years her anti-JCV index progressively declined to a level 0.6 unitsConclusionOur case raises the consideration to include vaccination as a factor that can affect JCV index and should be tallied during NTZ treatment mitigation.Copyright © 2016 Elsevier B.V. All rights reserved.
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