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Multicenter Study Clinical Trial
A prospective analysis of the outcome of levetiracetam in clinical practice.
- Andrew Nicolson, Sheila A Lewis, and David F Smith.
- Department of Neurology, Hope Hospital, Stott Lane, Salford M6 8HD, UK. andrew@nicolson71.freeserve.co.uk
- Neurology. 2004 Aug 10; 63 (3): 568-70.
AbstractIn this postlicensing surveillance study in a large unselected population, data were collected prospectively on all patients prescribed levetiracetam (LEV) at a regional epilepsy clinic over a 2-year period. Two hundred forty-five (69.2%) patients remained on LEV, with 8.8% achieving remission and some improvement in seizure control in 49.3%. Sedation was the most common adverse effect (10.7%), but mood disturbance was more likely to lead to discontinuation (4.8%). Cumulative probability of remaining on LEV at 12 months was 0.74 (95% CI 0.69 to 0.79). Factors predictive of a poorer retention were a greater number of previous antiepileptic drugs and a faster initial titration regimen.
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