• Epilepsy research · Dec 2008

    Clinical Trial

    Levetiracetam in newly diagnosed late-onset post-stroke seizures: a prospective observational study.

    • Vincenzo Belcastro, Cinzia Costa, Francesca Galletti, Alessia Autuori, Laura Pierguidi, Francesco Pisani, Paolo Calabresi, and Lucilla Parnetti.
    • Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.
    • Epilepsy Res. 2008 Dec 1; 82 (2-3): 223-6.

    AbstractLevetiracetam (LEV) monotherapy was investigated in 35 patients (pts) (16M/19F, 71.9+/-7.3 years of age) with late-onset post-stroke seizures (i.e. seizures occurring at least 2 weeks after an ischemic stroke) in a prospective open-label study. Overall, 27 pts (77.1%) achieved a condition of seizure freedom (defined as 1 year without seizures): 19 (54.3%) at a daily LEV dose of 1000mg, 7 (20.0%) at 1500mg, 1 (2.8%) at 2000mg. Four pts (11.4%) discontinued the drug because of intolerable side effects (drowsiness associated to gait disturbance in 1 pt, and aggressive behaviour in the remaining 3 pts); 3 pts were unresponsive at a dose of 3000mg, and 1 pt was lost at follow-up. These observations suggest that LEV exhibits safety and efficacy profiles which make it an optimal candidate as a first-choice drug against post-stroke seizures.

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