• Pharmacotherapy · May 1998

    Case Reports

    Elevated pancreatic enzymes after extended propofol therapy.

    • C J Possidente, F B Rogers, T M Osler, and T A Smith.
    • Department of Pharmacotherapy, Fletcher Allen Health Care, Burlington, Vermont 05401, USA.
    • Pharmacotherapy. 1998 May 1; 18 (3): 653-5.

    AbstractPropofol is a sedative hypnotic agent often administered for intensive care sedation. A 28-year-old man who suffered a severe head injury developed elevated pancreatic enzymes after receiving extended high-dosage propofol therapy. Amylase and lipase values gradually reduced toward normal after the drug was discontinued. Possible propofol-induced pancreatitis was reported with short-term but not with prolonged therapy. A definitive cause-and-effect relationship is unclear since head trauma also was reported to cause elevated pancreatic enzymes. Intensive care practitioners should be aware of this potential reaction.

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