• Flavia Venetucci Gouveia, Clement Hamani, Erich Talamoni Fonoff, Helena Brentani, AlhoEduardo Joaquim LopesEJLDepartment of Neurology, Division of Functional Neurosurgery of the Institute of Psychiatry, University of Sao Paulo School, Medicine School, Sao Paulo, Brazil., Rosa Magaly Campêlo Borba de Morais, Aline Luz de Souza, Sérgio Paulo Rigonatti, and Raquel C R Martinez.
• Laboratory of Neuroscience, Hospital Sirio-Libanes, Sao Paulo, Brazil.
• Neurosurgery. 2019 Jul 1; 85 (1): 113011-30.

AbstractAggressiveness has a high prevalence in psychiatric patients and is a major health problem. Two brain areas involved in the neural network of aggressive behavior are the amygdala and the hypothalamus. While pharmacological treatments are effective in most patients, some do not properly respond to conventional therapies and are considered medically refractory. In this population, surgical procedures (ie, stereotactic lesions and deep brain stimulation) have been performed in an attempt to improve symptomatology and quality of life. Clinical results obtained after surgery are difficult to interpret, and the mechanisms responsible for postoperative reductions in aggressive behavior are unknown. We review the rationale and neurobiological characteristics that may help to explain why functional neurosurgery has been proposed to control aggressive behavior.© Congress of Neurological Surgeons 2019.

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