• Future oncology · Feb 2018

    Nonprogression with avelumab treatment associated with gains in quality of life in metastatic Merkel cell carcinoma.

    • Howard L Kaufman, Matthias Hunger, Meliessa Hennessy, Michael Schlichting, and Murtuza Bharmal.
    • Massachusetts General Hospital, Boston, MA, USA.
    • Future Oncol. 2018 Feb 1; 14 (3): 255-266.

    AimTo assess the association between tumor response and health-related quality of life (HRQoL) in patients with metastatic Merkel cell carcinoma treated with the anti-PD-L1 avelumab.Materials & MethodsPhase II single-arm trial (NCT02155647) data of 88 patients were analyzed. Correlations between percentage reduction in tumor size and change from baseline in Functional Assessment of Cancer Therapy - General (FACT-G), FACT - Melanoma (FACT-M) and EuroQol-5 Dimension scores were calculated. HRQoL and utility by tumor response (per the Response Evaluation Criteria In Solid Tumors version 1.1) was estimated.ResultsTumor shrinkage correlated positively with patients' change from baseline in the FACT-M total (0.364 [95% CI: 0.050-0.607]) and subscale scores. Differences in HRQoL and utility between nonprogressive disease and progressive disease were clinically relevant.ConclusionIn patients with metastatic Merkel cell carcinoma, nonprogression during treatment with avelumab correlated with gains in HRQoL.

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