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Anasthesiol Intensivmed Notfallmed Schmerzther · Jun 2019
[Trauma-Induced Coagulopathy: Pathophysiology and Management].
- Christine Schlömmer and Jens Meier.
- Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Jun 1; 54 (6): 413-423.
AbstractPersistent, uncontrolled bleeding after trauma is one of the leading causes of fatalities in patients with severe injuries. 40% of trauma deaths are associated with massive haemorrhage. Hypoperfusion due to major loss of blood volume leads to tissue damage. In combination with acidosis and hypothermia, a generalized immune response with activation of coagulation is triggered. This leads to trauma-induced coagulopathy. A suitable, early treatment might lead to a significant reduction in morbidity and mortality.Georg Thieme Verlag KG Stuttgart · New York.
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