• Cell · Jan 2002

    Review

    Apoptosis: a link between cancer genetics and chemotherapy.

    • Ricky W Johnstone, Astrid A Ruefli, and Scott W Lowe.
    • Cancer Immunology Division, The Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, Smorgon Family Building, St. Andrews Place, East Melbourne, 3002 Victoria, Australia. r.johnstone@pmci.unimelb.edu.au
    • Cell. 2002 Jan 25; 108 (2): 153-64.

    AbstractDefects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.

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