• The Journal of pediatrics · Aug 2004

    Intracranial hemorrhage in premature neonates treated with extracorporeal membrane oxygenation correlates with conceptional age.

    • George E Hardart, M Kathleen M Hardart, and John H Arnold.
    • Division of Pediatric Critical Care, Department of Pediatrics, Morgan Stanley Children's Hospital of New York, New York 10032-3784, USA. gh2115@columbia.edu
    • J. Pediatr. 2004 Aug 1; 145 (2): 184-9.

    ObjectiveTo determine the effect of patient age on the risk of intracranial hemorrhage (ICH) in premature neonates treated with extracorporeal membrane oxygenation (ECMO).Study DesignThis was a retrospective cohort study of neonates of <37 weeks' gestation treated with ECMO in the years 1992 through 2000 and reported to the Extracorporeal Life Support Organization Registry (n=1524). The relation between ICH and patient age, defined as gestational age, postnatal age (PNA), and postconceptional age (PCA), was determined with the use of multiple logistic regression analysis.ResultsPNA was inversely correlated with ICH in the univariate analysis (P=.01) but not in the multivariate analysis (P=.36). PCA showed a strong univariate correlation with decreasing ICH: 26% of patients ConclusionsPostnatal age is not a strong independent predictor of ICH in premature neonates treated with ECMO. PCA is the best age-related predictor of ECMO-related ICH in premature infants.

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