• Anesthesiology clinics · Jun 2017

    Review

    Uterotonic Medications: Oxytocin, Methylergonovine, Carboprost, Misoprostol.

    • Cristianna Vallera, Lynn O Choi, Catherine M Cha, and Richard W Hong.
    • Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 3325, Los Angeles, CA 90095-7403, USA. Electronic address: cvallera@mednet.ucla.edu.
    • Anesthesiol Clin. 2017 Jun 1; 35 (2): 207-219.

    AbstractUterine atony is a common cause of primary postpartum hemorrhage, which remains a major cause of pregnancy-related mortality for women worldwide. Oxytocin, methylergonovine, carboprost, and misoprostol are commonly used to restore uterine tone. Oxytocin is the first-line agent. Methylergonovine and carboprost are both highly effective second-line agents with severe potential side effects. Recent studies have called into question the effectiveness of misoprostol as an adjunct to other uterotonic agents, but it remains a useful therapeutic in resource-limited practice environments. We review the current role these medications play in the prevention and treatment of uterine atony.Copyright © 2017 Elsevier Inc. All rights reserved.

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