• J Comp Eff Res · Mar 2016

    Review

    Comparative effectiveness of primary PCI versus fibrinolytic therapy for ST elevation myocardial infarction: a review of the literature.

    • Eleanor R Joy, John Kurian, and Chris P Gale.
    • York Teaching Hospital, NHS Foundation Trust, York, UK.
    • J Comp Eff Res. 2016 Mar 1; 5 (2): 217-26.

    AimTo compare the effectiveness of primary percutaneous coronary intervention (pPCI) and fibrinolytic therapy (FL) for the acute management of ST elevation myocardial infarction (STEMI).MethodsA review of guidelines and PubMed literature comparing clinical outcomes of patients with STEMI treated with pPCI or FL.ResultsEarlier trials reported reduced mortality and reinfarction with pPCI. Recent randomized data suggest similar outcomes for delayed pPCI compared with FL, especially in geographically remote areas. Guidelines recommend pPCI as the preferred reperfusion strategy for STEMI, if available within 120 mins of first medical contact.ConclusionpPCI is the preferred treatment strategy for STEMI. However, FL with subsequent percutaneous coronary intervention remains a viable option for those in rural areas.

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