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- A D Ormerod, L Smart, T M Reid, and A Milford-Ward.
- Department of Dermatology, University of Aberdeen, United Kingdom.
- Arch Dermatol. 1993 Mar 1; 129 (3): 343-6.
BackgroundFamilial cold urticaria is a rare cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown pathogenesis. Release of a chymotrypsinlike substance has been postulated. To date, no effective treatment has been reported.ObservationsEight cases from a large family pedigree are described. Three members showed a very favorable response in their cold urticaria, when treated with stanozolol; the response was reproducible. Histologic examination of an early lesion in one case revealed evidence of mast cell degranulation.ConclusionsThe biochemical observations are probably secondary epiphenomena. Correction of a deficiency of an inhibitory protein is a possible mechanism of action of stanozolol as in hereditary angioedema.
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