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Case Reports
Is there a role for rituximab in the treatment of idiopathic childhood nephrotic syndrome?
- Graham C Smith.
- Children's Kidney Centre, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK. smithgc@cardiff.ac.uk
- Pediatr. Nephrol. 2007 Jun 1; 22 (6): 893-8.
AbstractWe each have nephrotic patients who become steroid dependent and in whom multiple immunosuppressive agents are employed. There is a need to balance possible therapeutic benefits with drug toxicity. This case report describes such a patient, who has suffered from nephrotic syndrome for over 11 years and had become resistant to the usual therapies. He was therefore given a single dose of the anti-CD20 drug rituximab, to which he showed a prompt response, leaving him free of proteinuria for the past 10 months.
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