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- Megan V Caram and Scott M Schuetze.
- Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Michigan, USA.
- J Surg Oncol. 2011 Dec 1; 104 (8): 888-95.
AbstractGastrointestinal stromal tumor (GIST), the most common sarcoma arising in the gastrointestinal tract, typically expresses the tyrosine-kinase receptor, C-KIT, and contains activating mutation in the c-kit or platelet-derived growth factor receptor (pdgfr) gene. Recently, development of small molecules that inhibit the kinase activity of mutant C-KIT and PDGFR proteins has radically changed treatment and prognosis of patients diagnosed with advanced GIST as this molecularly "targeted" therapy has demonstrated remarkable high-level of activity in this disease.Copyright © 2011 Wiley Periodicals, Inc.
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