• Experimental dermatology · Sep 2010

    Review

    The biology of burn injury.

    • Lars H Evers, Dhaval Bhavsar, and Peter Mailänder.
    • Department of Plastic, Hand, Reconstructive Surgery, Burn Center, University of Lübeck, Lübeck, Germany. levers@gmx.net
    • Exp. Dermatol. 2010 Sep 1; 19 (9): 777-83.

    AbstractBurn injury is a complex traumatic event with various local and systemic effects, affecting several organ systems beyond the skin. The pathophysiology of the burn patient shows the full spectrum of the complexity of inflammatory response reactions. In the acute phase, inflammation mechanism may have negative effects because of capillary leak, the propagation of inhalation injury and the development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn care research. Conversely, inflammation is a necessary prologue and component in the later-stage processes of wound healing. In this review, we are attempting to present the current science of burn wound pathophysiology and wound healing. We also describe the evolution of innovative strategies for burn management.

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