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Proc. Natl. Acad. Sci. U.S.A. · Mar 2007
Innate response to self-antigen significantly exacerbates burn wound depth.
- Freeman Suber, Michael C Carroll, and Francis D Moore.
- Harvard Medical School, Boston, MA 02115, USA.
- Proc. Natl. Acad. Sci. U.S.A. 2007 Mar 6; 104 (10): 3973-7.
AbstractA major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.
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