• Pediatr. Infect. Dis. J. · Dec 2016

    Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children.

    • Synne Jenum, Sivakumaran Dhanasekaran, Christian Ritz, Ragini Macaden, T Mark Doherty, Harleen M S Grewal, and TB Trials Study Group.
    • From the *Department of Clinical Science, University of Bergen, Bergen, Norway; †Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway; ‡Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway; §Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; ¶Division of Infectious Diseases, St. John's Research Institute, Koramangala, Bangalore, India; and ‖GlaxoSmithKline, Vaccines, Wavre, Belgium.
    • Pediatr. Infect. Dis. J. 2016 Dec 1; 35 (12): 1336-1338.

    AbstractWe have explored the added value of interferon-γ (IFNγ)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.

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