• Urologia internationalis · Jan 2013

    The clinical significance of PCDH10 promoter methylation in patients with bladder transitional cell carcinoma.

    • Ying-Li Lin, Zhi-Gang Li, and Tong-Yu Guan.
    • Department of Urology, Xuzhou Tumor Hospital (Xuzhou Third People's Hospital), Xuzhou, China.
    • Urol. Int. 2013 Jan 1; 90 (2): 219-24.

    ObjectiveTo investigate the clinical significance of PCDH10 (protocadherin 10) promoter methylation in patients with bladder transitional cell carcinoma (TCC).Materials And Methods107 samples of bladder TCC and 38 normal bladder epithelial tissues were investigated using methylation-specific PCR, and the relationships between PCDH10 methylation and clinicopathologic features as well as patients' outcome were analyzed.ResultsPCDH10 methylation was detected in 63 (58.9%) bladder TCC samples, but no methylation of PCDH10 was found in controls. Moreover, PCDH10 methylation was significantly associated with larger tumor size (p = 0.0074), non-papillary shape (p = 0.0268), tumor relapse (p = 0.0029), high grade (p = 0.0397), advanced stage (p = 0.0004) and poor prognosis (p = 0.0009). In addition, multivariate analysis indicated that PCDH10 methylation is independently associated with poor outcome and may be used as a useful independent prognostic factor (p = 0.0255).ConclusionsPCDH10 methylation is closely associated with malignancy of bladder TCC and may be used as an independent predictor for patients with bladder TCC.Copyright © 2012 S. Karger AG, Basel.

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