• Rabie Soliman, Mohammed Mofeed, and Tarek Momenah.
• Department of Cardiac Anesthesia, Prince Sultan Cardiac Centre, Riyadh, Saudi Arabia; Department of Anesthesia, Faculty of Medicine, Cairo University, Egypt.
• Ann Card Anaesth. 2017 Jul 1; 20 (3): 313-317.

ObjectiveThe study was done to compare propofol and ketofol for sedation of pediatric patients scheduled for elective pulmonary valve implantation in a catheterization laboratory.DesignThis was a double-blind randomized study.SettingThis study was conducted in Prince Sultan Cardiac Centre, Saudi Arabia.Patients And MethodsThe study included 60 pediatric patients with pulmonary regurge undergoing pulmonary valve implantation.InterventionThe study included sixty patients, classified into two groups (n = 30). Group A: Propofol was administered as a bolus dose (1-2 mg/kg) and then a continuous infusion of 50-100 μg/kg/min titrated as needed. Group B: Ketofol was administered 1-2 mg/kg and then infusion of 20-60 μg/kg/min. The medication was prepared by the nursing staff and given to anesthetist blindly.MeasurementsThe monitors included heart rate, mean arterial blood pressure, respiratory rate, temperature, SPO2and PaCO2, Michigan Sedation Score, fentanyl dose, antiemetic medications, and Aldrete score.Main ResultsThe comparison of heart rate, mean arterial pressure, respiratory rate, temperature, SPO2and PaCO2, Michigan Sedation Score, and Aldrete score were insignificant (P > 0.05). The total fentanyl increased in Group A more than Group B (P = 0.045). The required antiemetic drugs increased in Group A patients more than Group B (P = 0.020). The durations of full recovery and in the postanesthesia care unit were longer in Group A than Group B (P = 0.013, P < 0.001, respectively).ConclusionThe use of propofol and ketofol is safe and effective for sedation of pediatric patients undergoing pulmonary valve implantation in a catheterization laboratory. However, ketofol has many advantages more than the propofol. Ketofol has a rapid onset of sedation, a rapid recovery time, decreased incidence of nausea and vomiting and leads to rapid discharge of patients from the postanesthesia care unit.

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