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Anesthesia and analgesia · Mar 2020
Comparative Study Observational StudyGene Variants in Hepatic Metabolism, Gamma-Aminobutyric Acid-ergic Reward, and Prostaglandin Pathways in Opioid-Consuming and Opioid-Naïve Patients Presenting for Lower Extremity Total Joint Replacement.
- Daniel W Odell, Ken B Johnson, Alan R Light, Ami R Stuart, and Kathleen C Light.
- From the Department of Anesthesiology, University of Utah, Salt Lake City, Utah.
- Anesth. Analg. 2020 Mar 1; 130 (3): e67-e70.
AbstractGene variants may contribute to individual differences in the experience of pain and the efficacy and reward of treatments. We explored gene variation in opioid-naïve and opioid-consuming patients undergoing elective lower extremity total joint replacement. We focused on 3 gene pathways including prostaglandin, gamma-aminobutyric acid (GABA)-ergic reward, and hepatic metabolism pathways. We report that for genes with possible or probable deleterious impact in these 3 pathways, opioid consumers had more gene variants than opioid-naïve patients (median 3 vs 1, P = .0092). We conclude that chronic opiate users may have genetic susceptibility to altered responses in reward/dependency and pain/inflammation pathways.
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