• Expert Rev Neurother · May 2008

    Review

    Frovatriptan for the acute treatment of migraine and prevention of predictable menstrual migraine.

    • Arthur H Elkind and E Anne MacGregor.
    • Elkind Headache Center, 12 North Seventh Avenue, Mount Vernon, NY 10550, USA. arthur.elkind@verizon.net
    • Expert Rev Neurother. 2008 May 1; 8 (5): 723-36.

    AbstractFrovatriptan is a 5-HT(1B/1D) receptor agonist that belongs to the triptan therapeutic class. Relative to other triptans, frovatriptan has a long half-life (26 h) and a low incidence of migraine recurrence (17%). Frovatriptan is indicated for the acute treatment of migraine with or without aura, and has a relatively good safety and tolerability profile. Recent studies have also shown that a 6-day regimen of frovatriptan scheduled during the perimenstrual period significantly reduced the incidence and severity of menstrual migraine (MM; attacks that regularly start day -2 to +3 relative to menses). Prevention may be important because MM attacks have been characterized as being of longer duration, more severe and more refractory to treatment than non-MM attacks.

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