• Journal of critical care · Oct 2019

    Multicenter Study

    Safety and efficacy of beta-blockers to improve oxygenation in patients on veno-venous ECMO.

    • Bunge Jeroen J H JJH Erasmus MC, University Medical Center Rotterdam, Department of Intensive Care, The Netherlands; Erasmus MC, University Medical Center Rotterdam, Thor, Soufiane Diaby, Ana L Valle, Jan Bakker, Diederik Gommers, Jean-Louis Vincent, Jacques Creteur, Fabio S Taccone, and Reis Miranda Dinis D Erasmus MC, University Medical Center Rotterdam, Department of Intensive Care, The Netherlands..
    • Erasmus MC, University Medical Center Rotterdam, Department of Intensive Care, The Netherlands; Erasmus MC, University Medical Center Rotterdam, Thoraxcenter, Department of Cardiology, The Netherlands. Electronic address: j.bunge@erasmusmc.nl.
    • J Crit Care. 2019 Oct 1; 53: 248-252.

    PurposeBeta-blockers (BB) may improve oxygenation in patients on veno-venous extracorporeal membrane oxygenation (V-V ECMO). This study analyzed safety and efficacy of BB in hypoxemic patients on V-V ECMO.Materials And MethodsRetrospective analysis of patients who were treated with BB during V-V ECMO in two centers. The primary safety outcome was a composite of occurrence of bradycardia or hypotension with need for intervention, resuscitation, unexplained rise in serum lactate, and discontinuation of beta-blockers for other reasons than inefficacy or resolution on hypoxemia during the first 5 days of therapy. The main efficacy outcome was increase in oxygen saturation (SaO2) within 12 h after start of BB.Results33 patients received BB for 4 [3-7] days while on V-V ECMO. Fifteen episodes of adverse events occurred in 13 patients (39%); BB had to be discontinued in only one patient for sustained hypotension. In two other patients, doses were reduced or temporarily withheld due to bradycardia. There was an increase in SaO2 from 92 [90-96]% to 96 [94-97]% at 12 h, with unchanged mean arterial pressure and norepinephrine doses.ConclusionsIn this study, use of BB in hypoxemic patients on V-V ECMO was safe and associated with a moderate increase in SaO2.Copyright © 2019 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.